The key difference between IVF and ICSI is how the sperm fertilises the egg. In IVF, the egg and sperm (of which there are multiple) are left in a petri dish to fertilise on their own. In ICSI, one sperm is directly injected into the egg.
One cycle of ICSI takes between four weeks and six weeks to complete. You and your partner can expect to spend a half-day at the clinic for the egg and sperm retrieval procedures. You will usually be asked to go back between two days and five days later for the embryo transfer procedure.
Initially, a sperm sample is prepared using multiple techniques in order to eliminate poor-quality sperm. The remaining specimen of “healthy” sperm is then placed under high-magnification for visual inspection by an embryologist. The embryologist will select the “best looking” sperm using a fine glass needle.
A small number of eggs – usually less than 5 percent – can be damaged as a result of the needle insertion
ICSI procedures could cause a little pain to the patient by doing needle aspiration and injection. The egg retrieval process is painless because the anesthesiologist will use anesthesia and sedation medication.
Individual sperm morphology assessed at the moment of ICSI does not seem to affect the fertilization rate or embryo development. However, the implantation rate was significantly lower when only embryos resulting from the injection of an abnormal spermatozoon were available.
If the total motile sperm count is below 1 to 5 million, success is unlikely. Therefore, in vitro fertilization with ICSI (injecting sperm into eggs) is usually done for couples with sperm numbers this low.
In a study comparing PICSI to ICSI using sibling oocytes, PICSI resulted in significantly higher fertilization rates (82.2% vs 70.5%), transfer-eligible embryo rates (51.1% vs. 38.1%), and a greater number of high-quality embryos, compared to ICSI.
Intracytoplasmic sperm injection (ICSI) is an infertility treatment. It involves injecting live sperm into a person's eggs in a laboratory. This procedure can create an embryo (fertilized egg).
Intracytoplasmic sperm injection (ICSI) is a technique used during in vitro fertilization (IVF) where a single sperm is injected directly into the egg for the purpose of fertilization.