Karyotyping
Infertility is on the rise. According to the United Nations, there was a worldwide average of 5 children per woman in 1950, but by 2020, that ratio had dropped to 2 children. Infertility affects 48 million couples and 186 million people globally, according to estimates.
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Karyotyping Chromosome Analysis Method
A karyotype analyses the structure, quantity, and organisation of a person's chromosomes. 46 chromosomes (23 pairs) make up a typical karyotype, including the sex chromosomes (XX for females and XY for males). A numerical change or structural rearrangement involving any of the chromosomes may lead to a genetic disorder or infertility.
Book AppointmentA karyotype analyses the structure, quantity, and organisation of a person's chromosomes. 46 chromosomes (23 pairs) make up a typical karyotype, including the sex chromosomes (XX for females and XY for males). A numerical change or structural rearrangement involving any of the chromosomes may lead to a genetic disorder or infertility.
Read MoreWhen a person exhibits congenital defects linked to a genetic condition, this test is conducted (e.g. abnormal physical features, behavioural problems, or developmental delays)If a couple has a history of miscarriages or failed implantations• There is a possibility that a foetus has a chromosomal anomaly.•A nearly unlimited variety of tissues, including blood, can be used for the test.• Chorionic villus, amniotic fluid, and other foetal products.
Read MoreKaryotype analysis is best carried out on cells that are dividing. When the genetic material is arranged into chromosomes during a given stage of cell culture, the cells are then arrested. Each cell's karyotype is visualised by staining the chromosomes and taking a microscope snapshot of them.A qualified scientist then uses specialised computer software to examine the image.
Read MoreA karyotype image is created by staining a cell's chromosomes with a dye and taking a microscope photo. A clinical scientist then uses specialised computer software to examine the image.Karyotype analysis is best carried out on cells that are in a stage of division. Chromosomes can be seen under a microscope at this point. The chromosomes exist as long, thin threads during the non-dividing stage.
Read MoreThe karyotype test results are typically available in 14–28 days. For a female, a normal karyotype is 46,XX, and for a male, it is 46,XY. Any variation is regarded as abnormal. The asking physician or genetic counsellor will explain the clinical importance of an aberrant karyotype and how it may affect a person's health or treatment plan.
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