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Genetic Disorders & Infertility

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Genetic Disorders & Infertility

Genetic factors such as Klinefelter syndrome (affecting approximately 1 in 1,000 males) and Y chromosome microdeletions (found in about 15% of men with low sperm counts or azoospermia) can significantly impair sperm production and lead to male infertility.

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General Infertility Causes

Genetic Disorders & Infertility Causes

Genetic disorders can play a significant role in male infertility by affecting sperm production, motility, and overall reproductive function. Certain genetic abnormalities can lead to azoospermia (absence of sperm), oligospermia (low sperm count), or sperm with abnormal morphology. These conditions can make natural conception difficult or impossible without medical intervention.

Some of the most common genetic conditions that contribute to male infertility include:

  • Klinefelter Syndrome (XXY Chromosome): Affects sperm production and testosterone levels, often leading to infertility.
  • Y-Chromosome Microdeletions: Missing genetic material on the Y chromosome can impair sperm production.
  • Cystic Fibrosis Gene Mutations: Often associated with congenital absence of the vas deferens (CAVD), preventing sperm transport.
  • Kallmann Syndrome: A disorder affecting hormone production, leading to low testosterone and infertility.

    • Genetic testing is crucial for diagnosing male infertility caused by genetic factors. Common diagnostic tests include:

  • Karyotyping: Examines chromosomal structure to detect abnormalities like Klinefelter syndrome.
  • Y-Chromosome Microdeletion Testing: Identifies missing genetic material affecting sperm production.
  • Cystic Fibrosis Gene Testing: Determines if mutations are affecting sperm transport.
  • Hormonal Tests: Evaluates testosterone and other hormone levels to assess reproductive function

    • Treatment options depend on the type and severity of the genetic disorder:

  • Assisted Reproductive Techniques (ART):Techniques like ICSI (Intracytoplasmic Sperm Injection) can help men with low sperm count or poor sperm motility achieve conception.
  • Hormonal Therapy: Can help in cases of hormonal imbalances due to genetic disorders like Kallmann syndrome.
  • Surgical Interventions: In some cases, sperm retrieval procedures like TESE (Testicular Sperm Extraction) can be used for men with non-obstructive azoospermia.
  • Genetic Counseling: Couples planning to conceive can benefit from counseling to understand risks and explore reproductive options. If you suspect genetic factors may be contributing to infertility, Jananam Fertility offers expert genetic screening, diagnosis, and treatment options tailored to your needs. Contact us today to explore your options for parenthood.

    • Genetic issues may arise as a result of multifactorial inheritance. This comprises the presence of one or more genes as well as exposure to environmental influences.Certain medical disorders like diabetes, heart issues, asthma, obesity, and malignancies do not all have a single hereditary aetiology.

    They are frequently connected to the interactions between several genes and specific environmental or lifestyle factors. Consequently, determining a person's likelihood of inheriting these illnesses is exceedingly difficult.

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    What our patients say...

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    Ankita Paul
    09:32 26 Feb 25
    This place is magical. Once you step in, you will know how positive the ambience and people are. Everybody from Doctors, to nurses, to reception Ma'am, Pharmacy guy, finance & Billing team, and not to forget our food team and building guards are incredibly polite, supportive and humble.I got success in my first attempt itself. Their charges are also economical and line of treatment is very simple. They won't put you in a loop and charge unnecessarily so please be rest assured that you are in safe hands.Dr. Vani and her team is experienced and always there to support you during and after your treatment. I really wish all the women who want to conceive, please go to Dr. Vani once. In my case, Fate played an important role in making me come here but I would like to recommend this place to everyone who is going through any fertility challenge. Stay blessed and positive.They have accommodation facility also available so in case you are from different city, you don't need to worry about anything. Just leave your worries outside and enter with positivity, rest everything will be taken care by Dr. and her team. You will not see any fancy billboards or advertisements about this clinic because Jananam is known for their work and results and not the branding.I am truly thankful to Jananam for everything.
    Priyanga Arul
    14:48 25 Feb 25
    The treatment you gave me, Iam four months pregnant, thanking you Dr.Vani madam and staff
    Hindumathi TK
    12:13 21 Feb 25
    Hi AllThis is our second visit to Jananam for our next baby.Due to age constraints, we were little afraid on the possibility of pregnancy.But, Again Jananam made it possible for us. I'm in my 5th month now and Thanks a Million to Dr.Vani Mam and all others who supported usFirst Review:Mark my Words. Jananam is the Final and Successful destination for childless couples.You would not have even heard of this Fertility Center, as there is no much advertisements as compared to others.But they are doing THE BEST JOB, silently with great hospitalityWe after trying multiple doctors and treatments, ended up at Jananam after seeing Google Reviews.I seriously have lost all my hope of child bearing in these 7 years of my marriage life facing failures only in any of my treatments.And it was diagnosed to be Unexplained Infertility! Hope you all know how it hurts!!!Thought of giving a last try at Jananam with no idea, except the positive Google Reviews.To our surprise, now I'm 12 weeks Pregnant :)We started our treatment on March 2021, and May 7th was MY DAY, When Dr. Vani Mam announced, it was a good and healthy pregnancy!!!I bow to Dr.Vani Mam, Dr. Mangalam Mam and Dr. Prema Mam, who were supportive and kind hearted.And our Special Thanks to the Sisters and Lab Technicians, who guided as throughout the treatment process without any mess.Also a special mention to the Receptionist, Billing person and the entire team for their prompt responses for our queries.Last but not least, they are doing excellent without any interruptions even during this corona pandemic times.Thank You Jananam!!! :)
    raji software
    09:20 21 Feb 25
    Hi this is Rajeswari Arunchakkaravarthi. I am very happy and greatful to write this review.I am one of the old patient of Jananam. I have been doing my ivf from 2016.My 1st experience in Jananam was amazing and easy. Dr. vani mam was one of the greatest Doctor and kindest human being I have met.She will treat us in very smooth and polite way, v can ask all our doubts, she'll answer it very kindly. Even all nurses and staffs are very friendly and helping. Canteen persons and food was also very good and healthy.I stayed in Jananam for 3 full months. It feeled like staying in my home.Rooms were very clean and tidy,bathroom was so hygienic.Food was on time,tasty and healthy.I have saw many fertility center, but Jananam was the only place I can trust.By God's grace and Dr. Vani mams help I conceived on 2024.now I am 4months pregnant. We are very thankful and greatful to Dr. vani mam and whole Jananam team. I strongly recommend Jananam fertility center,the one stop solution for all ur fertility problems.
    Safana Ameen
    17:58 18 Feb 25
    Hello, iam one of the patients among Jananam Fertility Centre (way to find our dream). Becoming a mother is one of the biggest dreams for every women. I was married for 6 years and still couldn't become a parent. Underwent so many treatment procedures in many different hospitals. Finally approached Jananam referred by one of our relatives and consulted Dr.Vani. Jananam is the place where every patient can be treated specifically special and their protocols and care after every procedures are worthy which eventually helps ppl to achieve their dream of becoming parents. Their advance treatment procedures and their effective responses for our doubts and their hospitality makes us warm and comfortable and also provide us with a strong confidence. Dr.Vani is the best doctor in treating infertility problems and also in counselling the patients and helping them to build confidence and hope within themselves. Nurses also respond politely and patiently anytime whenever we approach. Even the billing team and reception ppl also help patients, in their own way. Thanks to Dr.Vani Sundarapandian and her team for helping us to become what we desired for.
    Daphne Jonathaan
    17:40 15 Feb 25
    My experience at Jananam hospital has been overwhelmingly positive.From the moment I walked in, I felt welcomed and supported by the compassionate staff and Nurses.Dr.Vani mam is incredibly knowledgeable and took the time to explain everything clearly, answering all my questions with patience and understanding.The nurses are truly exceptional; they are kind, caring, and always went above and beyond to make me feel comfortable. The facilities are modern and clean, creating a calming and reassuring environment. Navigating fertility treatment can be a challenging journey, but Jananam hospital has made it so much easier with their expertise and genuine care. I highly recommend this hospital to anyone seeking fertility treatment; they are truly dedicated to helping their patients achieve their dreams.I am extending my heartfelt thanks Dr. Vani mam who works really hard to make our dreams come true.
    Dhakshnamoorthy J
    07:03 22 Jan 25
    'Jananam ' takes the best care, which actually made us feel like 'home'. Jananam was referred to us by a really great doctor from a big reputed health care centre, the strong recommendation for Jananam & Dr. Vani mam was immense.Jananam proved us how true it is. The way they care, replaced our fear into trust. Each and every steps were observed & performed by the main doctor, Dr. Vani mam itself. The procedure, the cost and everything is so transparent & not money minded at all. The warmth and the care the entire environment provide is such a bliss. Dr. Vani Mam's welcoming smile has flewed away our worries and she is so reachable for all the doubts. All the sisters and the working staffs (Anju, Yuvarani, Shaija, Aishwarya, Rebina, Tosmi, Parvin, Suguna,Karuthammal, Danalakshmi, Sineka, Yuvashree, Nithyanandan) are very approachable & kind to us. For every call we made to reception and to the sisters was immediately addressed and soughted out.Anybody who is reading this review and expecting for your little miracle to happen, please step in Jananam, Dr.Vani mam will guide you with exactly what you want & the entire Jananam will hold hands and help you to attain your little miracle happen.
    Asha Tara
    03:10 15 Jan 25
    My husband and I visited Jananam in May 2024 with lots of hopes. Dr. Vani was very friendly and knowledgeable in providing us with right recommendations. The nurses were very diligent and helpful in setting up subsequent meetings and follow ups. Overall, we returned with complete happiness. Jananam has played a very important role in our life.
    Geetha Mani
    09:39 04 Jan 25
    We were suggested Jananam Fertility Centre by a close friend of mine and We can't thank her enough. Dr Vani Mam is a Fertility medicine expert with splendid clinical acumen. She was quick to identify the possible obstacles in our journey to parenthood and suggest the best possible treatment. We are ever grateful to her for initiating us into the joy of pregnancy. I would like to add that she prescribes only the very necessary investigations and medications, maintaining high standards and ethics.The entire place has very positive vibes putting us at ease. All sisters are quick and kind in responding to our queries always with a smile. The reception staff help us fix and maintain appointments smoothly. The billing section staff, financial counsellor, lab staff, pharmacist all work in splendid coordination avoiding any stress for us. This also contributes to the shorter waiting times. They have a canteen above providing safe, tasty and affordable food. The entire place is neat and tidy thanks to the housekeeping staff.As someone who has undergone the stress associated with multiple cycles of fertility treatment we would definitely recommend Jananam for anyone longing for parenthood. This place and the people instill us with hope and work with us right from the first visit.
    kishore kumar babu
    11:19 01 Jan 25
    I recently visited Jananam Fertility center to seek treatment for fertility-related issues, and I am pleased to share my experience.The doctors at Jananam Fertility Center are highly skilled and knowledgeable. They took the time to explain the treatment options thoroughly and answered all my questions patiently. Their approach was reassuring and compassionate, which made the entire process less stressful.The nursing staff and administrative team were exceptionally supportive. They were approachable, attentive, and ensured that I was comfortable throughout the process.The hospital maintained transparency in terms of treatment plans, expected outcomes, and costs. There were no hidden charges, and everything was explained upfront.The hospital environment was clean, hygienic, and welcoming. It felt less like a medical facility and more like a place of hope.Over all, I highly recommend Jananam Fertility Center to anyone seeking fertility treatment. They combine expertise, care, and state-of-the-art facilities to ensure the best possible outcomes. We are very grateful to Dr Vani and entire team of Jananam fertility centre for making our life so meaningful.Rating: ⭐⭐⭐⭐⭐ (5/5)Feel free to adjust based on your specific experience!
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